Abstract
The atypical neuroleptic clozapine induces specific electroencephalogram changes, which have not been investigated by the use of the technique of Magnetoencephalography (MEG). A 2∗37 channel biomagnetic system (Magnes II, Biomagnetic Technologies, San Diego, CA) was used to record spontaneous magnetic activity for the frequency ranges (2–6 Hz), (7.5–12 Hz), (12.5–30 Hz) in schizophrenic patients and controls in two trials within 3 weeks. Our results lend strong support to the assumption of a significant elevation of absolute dipole values (dipole density maximum [ D max], dipole number [ D total], absolute and relative dipole density) in the fast frequency range (12.5–30 Hz) over the left hemisphere, especially in the temporoparietal region by clozapine.
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