Abstract
Polycystic kidney disease is one of the most common inheritable renal diseases, characterized by the formation of multiple fluid-filled renal cysts. This disease is a progressive and unfortunately incurable condition. A case of polycystic kidney with chronic renal failure in house musk shrew (Suncus murinus) is described. At clinical presentation, a 16-month-old Suncus murinus showed weight loss and coarse fur. Regarding the biochemical profile, total protein concentrations increased, resulting in a declined albumin: globulin ratio. Blood urea nitrogen and creatinine concentrations were markedly elevated, indicating the end stage of chronic renal failure. Serum amyloid A levels increased and revealed inflammatory reaction during the cyst formation. Histopathologically, multiple cysts were lined by a single layer of epithelial cells or low cuboidal epithelium. The contents were homogenous eosinophilic materials (mucopolysaccharides or mucoproteins) and these cysts contained abundant macrophages. There were also regeneration and dilatation of renal tubes and interstitial fibrosis. The atrophic glomeruli and glomerular capsules were thickened and hyalinized by dense amorphous mucopolysaccharides. These histopathological findings suggested that the pathogenesis of polycystic kidney disease shared a common mechanistic feature across species.
Highlights
Sci. 2022, 9, 123. https://doi.org/Polycystic kidney disease is one of the most common inheritable renal diseases, characterized by the formation of multiple fluid-filled renal cysts
Polycystic kidney disease is a progressive and incurable condition that can lead to critical morbidity and renal failure
Our results suggested that prominent macrophages infiltration and increased serum amyloid A (SAA) levels should be the hallmark of polycystic kidney in this laboratory species animal
Summary
Polycystic kidney disease is one of the most common inheritable renal diseases, characterized by the formation of multiple fluid-filled renal cysts. This disease affects more than 12 million people in the world with an incident estimated at 1/400 to 1/1000 births [1]. Polycystic kidney disease is a progressive and incurable condition that can lead to critical morbidity and renal failure. This lesion causes the progressive formation of cysts leading to eventually the end stage of renal failure. It is proposed that the most expedient way should be to eliminate this disease from future generations of the breeding group
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