Abstract
We provide evidence for the presence of cannabinoid CB2 receptors in some cellular types of the cochlea of the adult albino rat. Cannabinoids and their receptors are increasingly being studied because of their high potential for clinical use. As a hyperspecialized portion of the peripheral nervous system, study of the expression and function of cannabinoid receptors in the hearing organ is of high interest. Stria vascularis and inner hair cells express CB2 receptor, as well as neurites and cell bodies of the spiral ganglion. Cellular types such as supporting cells and outer hair cells, in which the expression of other types of functional receptors has been reported, do not significantly express CB2 receptors in this study. An up-regulation of CB2 gene expression was detected after an ototoxic event such as cisplatin treatment, probably due to pro-inflammatory events triggered by the drug. That fact suggests promising potential of CB2 receptor as a therapeutic target for new treatments to palliate cisplatin-induced hearing loss and other ototoxic events which triggers inflammatory pathways.
Highlights
There is an increasing body of research on molecular signalling in the cochlea with the expectation that a deeper understanding of cell damage and regeneration pathways could uncover potential targets for the treatment and prevention of auditory damage.In the context of searching for potential therapeutic targets against inner ear disorders, the study of cannabinoid receptors expression in the auditory organ is of great interest
Post-treatment Auditory steady-state responses (ASSR) recordings were found to be higher than pre-treatment ASSR recordings in the CDDP-treated animals, as it was previously described [30]
CB2 labeling was detected in the organ of Corti, in inner hair cells (IHC) (Fig 2)
Summary
There is an increasing body of research on molecular signalling in the cochlea with the expectation that a deeper understanding of cell damage and regeneration pathways could uncover potential targets for the treatment and prevention of auditory damage. In the context of searching for potential therapeutic targets against inner ear disorders, the study of cannabinoid receptors expression in the auditory organ is of great interest. Cannabinoid receptors modulate a large number of normal brain and bodily functions and have been. CB2 Receptor Expression in the Cochlea of Adult Albino Rat somos/feder, Universidad Autónoma de Madrid (to RRC) http://www.uam.es/, Fundación Universidad Autónoma de Madrid SMS http://fuam.es/. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript
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