Abstract
An experimental investigation was undertaken to assess the survival and functional capacities of splenic autotransplants. A total of 75 individual implants were created following splenectomy in 24 rabbits. Twelve implants consisted of the entire spleen and 63 of small pieces of splenic tissue. The former were implanted in the posterior peritoneum of the upper abdominal cavity and the latter in the omentum. Progressive degeneration of the implant was consistently found in the group with implantation of the entire spleen. Conversely, the small implants survived and were histologically compatible with normal splenic tissue. The functional status of such implants was assessed in terms of phagocytic ability, proliferative activity and response to immunization. Phagocytic and proliferative activities were significant, while the magnitude of the specific response to immunization could not be evaluated with certainty. The results of this study indicate that small splenic autotransplants are functionally far from inert and may be of potential benefit in children undergoing splenectomy for trauma.
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