Abstract
The aim of this study was to compare the anti-inflammatory activities of Spirulina maxima treated with ultrasonication and water extraction process. S. maxima extracted via ultrasonication showed low cytotoxicity (16.90%) in a normal human cell line, CCD-986sk. Especially, S. maxima ultrasonication extract showed the highest DPPH radical scavenging activities (46.82%) compared to water extract (31.30%) at 100℃. In addition, ultrasonication extract showed a high amount of flavonoids (21.60 ㎎/g) and total phenols (8.36 ㎍/mL). Nitric oxide production by 1.0 ㎎/mL of S. maxima ultrasonication extract strongly inhibited (1.3770 ㎛ 1.0 ㎎/mL of S. maxima ultrasonication extract, which shows strong antioxidant activities. Based on these results, it can be concluded that the ultrasonication process increase anti-inflammatory activity of S. maxima extract.
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