Abstract
Fine needle aspiration of breast is being performed from last several years. It is not uncommon to find giant cell on FNAC of breast smears .Giant cells arises from monocyte / macrophage lineage which are capable of fusion to form multinucleated giant cell. The common giant cell seen in breast on fna smears are foreign body , Langhan’s type , stromal giant cells , tumor giant cells and osteoclastic giant cell . It arises in benign as well as malignant lesions of the breast. Hence, their recognition and correct interpretation can be valuable to cyto pathologist who identifies the variation in diagnosis of pathology and to the clinician for the treatment modalities of different breast pathologies.
Highlights
Multinucleated giant cell in breast tissue were described originally by Rosen in 1979.1 Multinucleated giant cell have been described in several breast pathologies raising an interesting differential diagnosis
Noncaseating granulomas are seen in sarcoidosis which may a create confusion because of possibility of confusion with other granulomatous lesions, a confirmation of diagnosis of tubercular mastitis is done by demonstration
Foreign body type giant cell is usually seen in fat necrosis, foreign body reaction
Summary
Tuberculosis of breast is not uncommon in Indian set up. It may mimic carcinoma with lymph node metastatis because of presence of firm breast mass with enlarged node. Cytological examination of breast reveals granulomas, epitheloid cells, multinucleated giant cell of Langhan’s type and caseous necrosis.[4] The cytological features of granulomatous mastitis may overlap. Noncaseating granulomas are seen in sarcoidosis which may a create confusion because of possibility of confusion with other granulomatous lesions, a confirmation of diagnosis of tubercular mastitis is done by demonstration.
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