Abstract
Spectroscopic (IR, 1H-NMR, UV-visible, mass and ESR spectra) and structural studies of the ligand (1E, N'Z, N'Z)-N', N'-bis (2-hydroxybenzylidene)-2-(naphthalen-1-yloxy) acetohydrazonohydrazide (H2L) and its metal complexes are reported. The magnetic properties and thermal analyses (DTA and TGA) were also carried out. The IR spectra of the prepared complexes suggested that, the ligand adopted either a bidentate or a tetradentate fashion, bonding to the metal ion through the azomethine nitrogens and the two phenolic oxygen atoms (ONNO). Electronic spectra and magnetic susceptibility measurements revealed an octahedral geometry for all complexes except sliver(I) complex (6), copper(II) complex (7) and cobalt(II) complex (11). The elemental analyses and mass spectral data have justified the ML, ML2 and M3L composition of the complexes. The ESR spectra of copper(II) complexes (5), (7), (12) and (16), showed an axial type (dx2-y2) ground state with a covalent bond character and also support the suggested structures of complexes. The antimicrobial activity as well as the cytotoxicity of the ligand and its metal complexes were investigated and discussed.
Highlights
New synthetic compounds with novel mechanism of action have become an important task to cope with drug resistance problems
Literature survey on structural behavior of hydrazine complexes reveals some interesting features of its coordination behavior
In view of the above facts, this article aimed to synthesize and identify new metal complexes derived from a hydrazine Schiff base ligand
Summary
New synthetic compounds with novel mechanism of action have become an important task to cope with drug resistance problems. Many organic drugs require interaction with metals in order to enhance their activity. They interact with metals at their target site or during their metabolism or disturb the balance of metal ion uptake and distribution in cells and tissues. Hydrazine offers the possibility of different modes of coordination towards transition metal ions. It can function as a monodentate and or bridging bidentate ligand [2,25]. In view of the above facts, this article aimed to synthesize and identify new metal complexes derived from a hydrazine Schiff base ligand. The antimicrobial activity of some metal complexes against Aspergillus fumigates,Candida albicans, Streptococcus pneumonia, Bacillis subtilis, Pseudomonas aeruginosa and Escherichia coli was investigated
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