Abstract
A simple, rapid, cost effective and extractive UV-Vis spectrophotometric method has been developed for the determination of Rufinamide(RFM) in bulk drug and pharmaceutical formulation. It was based on UV-Vis spectrophotometric measurements in which the drug made a complex with ?-naphthol in alkaline medium and give stable pale yellow colored complex which exhibits absorption maximum at 540 nm. Beer’s law was obeyed in the concentration range of 2 - 24 ?g /ml. This method was tested and validated for various parameters according to ICH guidelines. The proposed method was successfully applied for the determination of RFM in oral formulation. The results demonstrated that the procedure is accurate, precise and reproducible (relative standard deviation < 2 %). As it is simple, cheap and less time consuming, it can be suitably applied for the estimation of RFM in dosage forms in quality control labs.
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