Abstract
A novel spectrophotometric method was established for the determination of chlorpromazine (CPZ) and its related drugs. The method is based on ternary complex formation among o -sulfophenylfluorone, molybdenum(VI) and CPZ. In the determination of CPZ, Beer's law is obeyed in the range of 0.2∼7.0 μg ml−1. The effective molar absorptivity at 525 nm and the relative standard deviation were 4.6 × 104 dm3 mol−1 cm−1 and 2.4% (n = 6), respectively. The method was successfully applied to assays of CPZ and its related drugs in pharmaceutical preparations. The proposed method, requiring no solvent extraction, should be useful for a simple and sensitive determination of CPZ and its related drugs.
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