Abstract
A highly sensitive spectrofluorimetric method was developed for the analysis of four fluoroquinolones (FQs) antibacterials, namely norfloxain (NOR), lomefloxacin (LOM), pefloxacin (PEF), and levofloxacin (LEV), in their pharmaceutical dosage forms or in biological fluids through charge transfer (CT) complex formation with tetracyanoethylene (TCNE). The TCNE was found to react with these drugs to produce stable complexes, and the fluorescence intensity of the complexes was greatly enhanced. The formation of such complexes was also confirmed by infrared measurements. Optimum conditions for the formation of CT complexes have been investigated. Under optimum conditions, the detection limits were 1.0, 0.6, 0.8, and 0.4 ng mL−1 for NOR, LOM, PEF, and LEV, respectively, while the range of application was 2.0–900 ng mL−1 for all four drugs. The method has been successfully applied to determine their pharmaceutical dosage forms with good precision and accuracy. They were also applied for the determination of studied drugs in human urine samples.
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