Abstract
This study examines the ability of RTVue, Cirrus and Spectralis OCT Spectral domain-optical coherence tomographs (SD-OCT) to detect localized retinal nerve fiber layer defects in glaucomatous eyes. In this observational case series, four glaucoma patients (8 eyes) were selected from the University of California, San Diego Shiley Eye Center and the Diagnostic Innovations in Glaucoma Study (DIGS) based on the presence of documented localized RNFL defects in at least one eye confirmed by masked stereophotograph assessment. One RTVue 3D Disc scan, one RTVue NHM4 scan, one Cirrus Optic Disk Cube 200x200 scan and one Spectralis scan centered on the optic disc (15x15 scan angle, 768 A-scans x 73 B-scans) were obtained on all undilated eyes within a single session. Results were compared with those obtained from stereophotographs. In 6 eyes the presence of localized RNFL defects was detected by stereophotography. In general, by qualitatively evaluating the retinal thickness maps generated, all SD-OCT instruments examined were able to confirm the presence of localized glaucomatous structural damage seen on stereophotographs. This study confirms SD-OCT is a promising technology for glaucoma detection as it may assist clinicians identify the presence of localized glaucomatous structural damage.
Highlights
Optical coherence tomography (OCT) is a non-invasive imaging technique that has found extensive application in ophthalmology [1]
The purpose of this study is to describe the ability of RTVue, Cirrus and Spectralis OCT instruments to detect the presence of localized retinal nerve fiber layer defects identified by stereophotography in glaucoma patients
The Spectral domain-optical coherence tomography (SD-OCT) sectoral or clock hour retinal nerve fiber layer thickness (RNFL) thickness measurement corresponding to the defect location or closest to the defect location was reported for both RTVue and Cirrus
Summary
Optical coherence tomography (OCT) is a non-invasive imaging technique that has found extensive application in ophthalmology [1]. RTVue (Optovue Inc, Fremont, CA), Cirrus HD-OCT (Carl Zeiss Meditec, Dublin, CA) and Spectralis OCT (Heidelberg Engineering, Dossenheim, Germany) are 3 of the available commercial instruments that employ SD-OCT technology to obtain cross-sectional and three-dimensional images of the RNFL and the optic disc. These recently introduced devices, because of the high frame transfer rate and fast Fourier transform algorithm, can perform up to 27,000 A-scans per second with a depth resolution of approximately 5 microns [10,11]. The purpose of this study is to describe the ability of RTVue, Cirrus and Spectralis OCT instruments to detect the presence of localized retinal nerve fiber layer defects identified by stereophotography in glaucoma patients
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
