Abstract
Interaction of the meso-substituted carbocyanine dye 3,3′-diethyl-9-chlorothiacarbocyanine (DCTC) perchlorate with DNA in phosphate buffer solutions (pH 7) was studied by spectral and kinetic methods. It was shown that the dye mainly exists in the cis-isomer form in water and aqueous-alcoholic solutions. The interaction with DNA leads to the formation of a trans-DCTC complex, which gradually (over a few tens of minutes) converts into the complex of the dye cis-isomer. It was revealed that the reactant concentration and ionic strength of solution have a considerable effect on the kinetic characteristics of trans-cis-reorganization of DCTC complexes, thus indicating a complex character of the process.
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