Abstract
The crystal structure of spiro[2.2”]acenaphthene-1”-onespiro[3.3’]-5’-(2,3-dichlorophenylmethylidene)-1’-methylpipe-ridin-4’-one-4-(2,3-dichorophenyl) octahydroindolizine was elucidated by single crystal X ray diffraction. The title compound C37H30Cl4N2O2, crystallizes in the orthorhombic system, space group P212121 with a = 8.4610(4) , b = 16.0926(6) , c= 23.8997(11) and Z = 4. The central piperidine ring adopts twisted conformation, the piperidine of octahydroindolizine ring is in chair conformation and the pyrrole ring is in slightly twisted envelope conformation. Details of the synthesis, NMR, crystal structure determination and intra- and inter- molecular interactions of the compound are given.
Highlights
The crystal structure of spiro[2.2”]acenaphthene-1”-onespiro[3.3’]-5’-(2,3-dichlorophenylmethylidene)-1’-methylpiperidin-4’-one-4-(2,3-dichorophenyl) octahydroindolizine was elucidated by single crystal X-ray diffraction
The central piperidine ring adopts twisted conformation, the piperidine of octahydroindolizine ring is in chair conformation and the pyrrole ring is in slightly twisted envelope conformation
Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis (MTB), which usually infects the lungs but may affect the other parts of the body
Summary
Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis (MTB), which usually infects the lungs but may affect the other parts of the body. This is one of the most prevalent diseases responsible for the death of approximately one billion people during the last two centuries. Perumal et al reported an atom economic synthesis and evaluation of antimycobacterial activities of spiro pyrido-pyrrolizines and pyrrolidines, [8,9] which inhibited in vitro MTB and multi-drug resistant Mycobacterium tuberculosis (MDR-TB).
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