Abstract
VACCINATION against malarial infections remains a goal to be achieved. Even if it were feasible, it might be difficult to obtain necessary amounts of the parasitic antigen, and only homologous species or strains of the parasite may be immunologically effective. Protective immunity is often a highly strain specific phenomenon as has been shown in experiments using the blood stages of the parasite as the immunizing agent1,2. Strain specificity of the immune response also occurs in natural human malaria3. Our aim was to determine whether a strict strain and species specificity occurs in animals vaccinated with sporozoites, or if a much broader spectrum of protective immunity develops.
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