Abstract
Background: Specific sensitization characterizes increased serum level of IgE to different groups of allergens (food, dust, domestic and contact). Characteristic of specific sensitization changes with age of patient. Spectrum of specific sensitization determined environmental factors, conditions of habitation. Objective: objective was to research characteristic of specific sensitization in patients with atopic dermatitis. Methods: There were 108 patients with atopic dermatitis, 1st group – 31 patient (17 boys and 14 girls) 0-3y.o., 2nd group – 30 (13 boys and 17 girls) 4-13 y.o., 3rd group – 47 (16 men and 31 women) 16-63 y.o. In control group, there were 25 patients (4 men, 21 women) 16-64 y.o. with another dermatological diseases such as psoriasis, acne, rosacea and etc., without atopic dermatitis. In patients of all 4 groups evaluated personal, family allergic anamnesis, drug and food allergy, sensitization by measuring common and specific levels of immunoglobulin E. Results: 10%, 32%, 27% patients of 1st, 2nd, 3rd groups had food allergy. The main allergens were citruses (37% cases), chocolate (27%) and milk (17%). Conclusion: 44-52% patients with atopic dermatitis and 4% patients without atopy had non-specific sensitization, that characterized five-fold increased serum level of IgE and more. 50-60% patients with atopic dermatitis had specific sensitization. 60% infants at the age under 3 y.o. with atopic dermatitis had sensitization for epithelium of homepets, 50% - for milk, 30% - white-egg. Among adults with atopic dermatitis sensitization was the same, as in control group. 35% patients with dermatoses without atopy had specific sensitization.
Highlights
There are currently two major pathogenetic forms of atopic dermatitis: truly allergic or allergic and atopiform or non-allergic
Specific hypersensitivity is characterised by increased levels of immunoglobulin E to various allergen groups [3]
The purpose of the study was to determine the nature of specific hypersensitivity in patients with atopic dermatitis in relation to ageing
Summary
There are currently two major pathogenetic forms of atopic dermatitis: truly allergic or allergic and atopiform or non-allergic. The allergic (extrinsic) form is associated with hypersensitivity to food and/or other allergens as well as increased levels of IgE in patients and is observed in 70– 80% of patients. The non-allergic (intrinsic) form is characterised by normal levels of IgE and is observed in 20– 30% of patients [1,2]. Specific hypersensitivity is characterised by increased levels of immunoglobulin E to various allergen groups (food, dust, household, and contact) [3]. Changes in the nature of food, dust, and household hypersensitivity are observed with age. Specific sensitization characterizes increased serum level of IgE to different groups of allergens (food, dust, domestic and contact). Characteristic of specific sensitization changes with age of patient. Spectrum of specific sensitization determined environmental factors, conditions of habitation
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
