Abstract
The use of sub-human primates is widespread in toxicological studies, but in general there is little background metabolic data available in this species. In the present studies, the baboon and rat were compared, on the basis of their hepatic drug-metabolising enzyme activity, to evaluate the use of baboons as a laboratory model. Studies of hepatic drug-metabolising enzymes in man in vivo are difficult to correlate with those from animals.
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