Abstract
The rates of the association and dissociation reactions of ouabain with (Na + + K +)-ATPase (ATP phosphohydrolase EC 3.6.1.3) were compared. The enzymes were prepared from kidney, heart and brain tissues obtained from guinea pig, dog and cat. The rate of dissociation of ouabain from (Na + + K +)-ATPase varied about 60-fold between different species. The dissociation rate also differs between tissues within a given species. The rate of association of ouabain with these enzyme preparations did nog differ appreciably. The results suggest that the species differences in sensitivity to the cardiac glycosides are principally related to the different rates of dissociation of the drug-enzyme complex.
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Schedule a callMore From: Biochimica et Biophysica Acta (BBA) - Biomembranes
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