Abstract
Pharmaceutical initiatives use analytical tools to monitor powders flowing through granulating, blending, and tablet formation steps. Two critical parameters that drive the quality and efficiency of drugs are the concentration of actives in the tablet, and the dissolution properties of the tablet. In order to ensure that these are within the target design space, it is important that component concentrations, particle size distributions, and cluster size are monitored throughout the manufacturing process. Standard optical techniques detect scattered light from spots that encompass many components in the blend. Efforts to extract composition and blend uniformity based on chemometric analyses are complex and often intractable. A highly spatially resolved spectral imager could simplify the chemometrics if the effective spatial resolution can separate most particles from neighboring particles. The effective spatial resolution is a function of the incident spot size, multiple scattering events, and the collection optics. This paper assesses the degree of spectral mixing due to particle-particle scattering as a function of incident spot size. Our real-time optical design is enabled by a high spectral brightness supercontinuum source, a MEMs-based spectral scan mechanism, confocal spatial scanning optics, and high gain * bandwidth detection.
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