Abstract
The existence of a relationship between surface potentials in the QRS complex on one hand, and left ventricular weight and wall thickness on the other was demonstrated in 150 individuals studied by orthogonal electrocardiography (Frank lead system) and biplane angiocardiography. Equations for the estimation of left ventricular weight and wall thickness were derived from data on that same series. They were based on two simple spatial voltage criteria together with the subject's age and weight. It was shown that the simple voltage criteria provide rather reliable means of detecting conditions of left ventricular overload. With a cut-off point corresponding to a 5% false positive rate, one of the two criteria had a false negative rate of only 33 % for left ventricular overload. Moreover, only a minority of these false negative subjects had left ventricular hypertrophy in terms of heart weight as a fraction of body weight.
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