Spatial Mixture Modelling for the Joint Detection-Estimation of Brain Activity in fMRI

Abstract

Within-subject analysis in event-related functional magnetic resonance imaging (fMRI) first relies on (i) a detection step to localize which parts of the brain are activated by a given stimulus type, and then on (ii) an estimation step to recover the temporal dynamics of the brain response. Recently, we have proposed a Bayesian detection-estimation approach that jointly addresses (i)-(ii). This approach provides both a spatial activity map and an estimate of brain dynamics. Here, we consider an extension that accounts for spatial correlation using a spatial mixture model (SMM) based on a binary Markov random field. It allows us to avoid any spatial smoothing of the data prior to the statistical analysis. Our simulation results support that SMM gives a better control of false positive (specificity) and false negative (sensitivity) rates than independent mixtures.