Abstract
BackgroundKashin-Beck disease (KBD) is one of the major endemic diseases in China, which severely impacts the physical health and life quality of people. A better understanding of the spatial distribution of the health loss from KBD and its influencing factors will help to identify areas and populations at high risk so as to plan for targeted interventions.MethodsThe data of patients with KBD at village-level were collected to estimate and analyze the spatial pattern of health loss from KBD in Bin County, Shaanxi Province. The years lived with disability (YLDs) index was applied as a measure of health loss from KBD. Spatial autocorrelation methodologies, including Global Moran’s I and Local Moran’s I, were used to describe and map spatial clusters of the health loss. In addition, basic individual information and environmental samples were collected to explore natural and social determinants of the health loss from KBD.ResultsThe estimation of YLDs showed that patients with KBD of grade II and patients over 50 years old contributed most to the health loss of KBD in Bin County. No significant difference was observed between two genders. The spatial patterns of YLDs and YLD rate of KBD were clustered significantly at both global and local scales. Villages in the southwestern and eastern regions revealed higher health loss, while those in the northern regions exhibited lower health loss. This clustering was found to be significantly related to organically bound Se in soil and poverty rate of KBD patients.ConclusionsOur results suggest that future treatment and prevention of KBD should focus on endemic areas with high organically bound Se in soil and poor economic conditions. The findings can also provide important information for further exploration of the etiology of KBD.
Highlights
Kashin-Beck disease (KBD) is one of the major endemic diseases in China, which severely impacts the physical health and life quality of people
Study population Overall, 1.34% of the investigated population were reported suffering from KBD in Bin County, with no new cases discovered in children
Farmers were the main occupation for KBD patients. 39.9% never received education, and 19.2% were from poor poverty-stricken households whose annual net income per capita was lower than 2950 RMB
Summary
Kashin-Beck disease (KBD) is one of the major endemic diseases in China, which severely impacts the physical health and life quality of people. Kashin-Beck disease (KBD) is a chronic, endemic, deformative osteoarthropathy, which is known for the formation of multi-joint hyperplasia bone changes [1]. In China, KBD has been effectively controlled and even eliminated in most affected areas, Wang et al BMC Public Health (2021) 21:387 but the number of existing patients is huge. According to the 2018 health statistics issued by the Chinese Ministry of Health [5], there were currently 177,018 individuals affected by KBD in 379 counties of 13 provinces or autonomous regions, and the largest number was found in Shaanxi Province (60,157 individuals), accounting for 34.0% of the total existing patients with KBD. The life quality of these existing patients still needs to be taken seriously
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