Abstract
The microtubule-severing enzyme spastin is an important regulator of microtubule dynamics and its mutation is implicated in hereditary spastic paraplegia. In addition to severing microtubules, spastin also slows their depolymerization and promotes their transition from shrinkage to growth (rescue). This activity, in combination with severing, can lead to the amplification of microtubule number and mass. The effects of spastin on microtubule dynamics may be enhanced by its observed accumulation on the tips of shrinking microtubules, but the mechanism of tip accumulation is unclear.
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