Abstract
1. The chief laryngeal spaces of the human larynx are the preepiglottic space (PES), the paraglottic space (PGS), and the cricoid area (CA). 2. The PES, PGS, and CA are a loose connective tissue (areolar tissue) areas composed of adipose tissue and loose elastic and collagen fibers. 3. The PES exists not only anterior to but also posterolateral and inferolateral to the epiglottis. 4. The posterior end of the PES is located in the vicinity of the anteroposterior midpoint of the thyroid lamina. 5. The PGS exists medial to the thyroid lamina. 6. The PES is adjacent to the PGS posteroinferiorly and is separated by fibrous tissue (the thyroglottic ligament). Posterosuperiorly, the PES and the PGS are not clearly delineated from each other. 7. The CA is located along the superior portion of the cricoid arch on both sides. 8. Cancer invasion into the CA and intravascular tumor invasion facilitate metastasis to the prelaryngeal, pretracheal, and/or paratracheal regions and facilitate stomal recurrence.
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