Cancer Research | VOL. 82
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Space Is the Place: Mapping the Cell–Cell Interactions That Predict Immunotherapy Responses in Melanoma

Publication Date Sep 16, 2022

Abstract

Abstract Although immune checkpoint inhibition (ICI) has revolutionized the treatment of advanced melanoma, reliable predictive biomarkers are still lacking. In this issue of Cancer Research, Antoranz and colleagues used RNA sequencing and multiplexed IHC to study the spatial immune landscape of pretreatment melanoma specimens from patients who either responded or did not respond to antiprogrammed death protein 1 (PD-1) therapy. The authors identified the spatial interaction between cytotoxic T cells and M1-like macrophages expressing PD-L1 at the tumor boundary as predictive of responses to immune checkpoint inhibition. These studies pave the way for the development of new spatial biomarkers to identify patients most likely to benefit from ICI therapy. See related article by Antoranz et al., p. 3275

Concepts

Predict Immunotherapy Responses Immune Checkpoint Inhibition Therapy Reliable Predictive Biomarkers Immune Checkpoint Inhibition Tumor Boundary Related Article RNA Sequencing Spatial Landscape Treatment Of Melanoma Development Of Biomarkers

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No potential conflict of interest was reported by the authors. The conception and design of the study, acquisition of data, analysis and interpretatio...

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