Abstract
Cyclin D1 (CCND1) protein overexpression and/or the t(11;14)(q13;q32) translocation are the pathognomonic hallmarks of mantle cell lymphoma (MCL). However, there have been cases that lacked both t(11;14) and cyclin D1 protein but still had a gene expression profile suggesting a diagnosis of MCL. SOX11 expression was detected in most cyclin D1- negative MCL and can serve as a specific biomarker for the diagnosis of this subset of MCL. Lack of SOX11 expression in MCL was associated with an indolent subset and favorable prognosis.
Highlights
Mantle cell lymphoma (MCL) is a distinct subtype of non-Hodgkin lymphoma [1]
Cyclin D1 (CCND1) overexpression has been detected in 90 % of MCL patients [3]
SOX11 expression can help distinguish MCL from other B cell lymphomas like chronic lymphoid leukemia (CLL) as most of them do not stain for SOX11 [12, 13]
Summary
Mantle cell lymphoma (MCL) is a distinct subtype of non-Hodgkin lymphoma [1]. The immunophenotype of the cells resembles the lymphocytes in the mantle zone of normal germinal follicles, and is characterized by coexpression of B-cell antigens (CD19+, CD20+, CD22+, CD43+, CD79+, surface immunoglobulin sIgM+, sIgD+) and the T-cell associated marker CD5+. SOX11 C1 monoclonal antibody was used to detect the SOX11 expression in MCL using immunofluorescence and flow cytometry studies. The gene was detected in all MCL cases studied, including CCND1 negative MCL cases. SOX11 expression can help distinguish MCL from other B cell lymphomas like chronic lymphoid leukemia (CLL) as most of them do not stain for SOX11 [12, 13].
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