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Abstract
Peripheral neuropathy (PN) is a difficult disease to manage. Symptomatic treatment focuses primarily on pain relief, using NSAIDs, opioids, tri-cyclic antidepressants, and selective serotonin norepinephrine reuptake inhibitors. There is potential for ultrasound transdermal drug delivery to improve the quality of care provided to patients with PN, since it is well-suited to peripheral nerves which are close to the skin. In addition, targeted delivery avoids many of the systemic consequences of taking a drug. We developed a wearable ultrasound drug delivery system called “SonoBandage” that combines low-impedance miniaturization of ultrasound transducer, RF electronics, and battery power supply, with a novel hydrogel coupling bandage loaded with salicylic acid NSAID. The design of the SonoBandage allows the device to be used over a range of ultrasound frequencies (0.1–3 MHz), intensities (0.1–3 W/cm2), and durations (0.25–4 h) increasing system flexibility for drug delivery protocols. The SonoBandage with NSAID was evaluated on a bench-top model with freshly harvested porcine skin and synthetic biomimetic human skin membrane (Millipore Inc). Across the n = 40 samples studied, salicylic acid drug flux was increased by 2–20x as compared to control samples (p < 0.01) after 1–4 h of ultrasound treatment. SonoBandage has potential to be used as a practical NSAID delivery platform for peripheral neuropathy.
Published Version
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