Abstract
Studies have been carried out on the interference phenomenon with certain neurotropic viruses in experimental animals. The primary object was to investigate claims that material containing human poliomyelitis virus interferes with the progress of the infection by the MM virus in hamsters, or the Lansing virus in mice. We have failed to find evidence that the inoculation of specimens known to contain human poliomyelitis virus interferes with the progress of MM or Lansing virus infections, and we do not believe that the interference phenomenon can be used in this way as a diagnostic test. In the course of this investigation, it was found that interference occurs when hamsters are inoculated cerebrally with lymphocytic choriomeningitis virus, and, four to seven days later, with the antigenically unrelated MM virus by the peritoneal route. A significant number of such treated animals are spared from developing paralysis due to the MM virus. Evidence was also obtained that under certain circumstances the inoculation of MM virus may lessen the severity of the illness due to lymphocytic choriomeningitis virus injected several days earlier.
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