Abstract
This chapter discusses some effects of aging and lipid-lowering drugs on lipid metabolism and the hepatic endoplasmic reticulum. Certain effects of aging, reproductive status and lipid-lowering drugs on lipid metabolism, liver structure and hepatic drug metabolizing enzymes in male Sprague-Dawley, Holtzman strain rats are presented in the chapter. Retired breeder rats have statistically higher serum cholesterol levels and a shorter life expectancy than age-matched virgin counterparts. The retired breeder rat may be a suitable animal model for testing lipid-lowering agents and the pathogenesis of certain types of hyperlipoproteinemia. Oxandrolone may be an unusually potent hypocholesterolemic agent capable of inducing the proliferation of hepatic smooth endoplasmic reticulum without an associated increase in drug-metabolizing enzymes.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
