Abstract
The presence of a kininase and a kininogenase was demonstrated in unheated human plasma proteins. The kininase was found to inactivate synthetic brady kinin and a kinin‐like substance released from a kininogen‐like material in unheated plasma proteins by human urinary kallikrein. It was heat‐labile and inhibited by EDTA, HgCl2 and 1,10‐phenanthroline. This enzyme was estimated to be kininase I from its inhibition pattern. Inactivation of the kininase revealed the presence of a kininogenase. Five per cent heat‐treated human plasma protein solution has been demonstrated to have no kininase activity but to contain the kinin‐like substance. A mechanism for the formation of the kinin‐like substance in 5 per cent heat‐treated plasma protein solution was discussed in terms of these kinin forming components present in the unheated plasma proteins.
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