Abstract

cardiovascular endpoints that we found between the 2 areas. Also, the fact that the mortalities of stroke and coronary heart disease in Japan have substantially changed during the past decades cannot explain our findings. Regrettably, our data did not allow separate analyses for hemorrhagic stroke and cerebral infarction, although we agree that it would be worthwhile examining these different types of stroke. We did examine coronary heart disease mortality, but the number of events was very small and HRs were unstable. In Tanushimaru, the HRs for coronary heart disease mortality were 1.68 (95%CI, 0.64– 4.42) in the mid category and 1.76 (95%CI, 0.60–5.20) in the upper category of systolic BP, compared to the lower category. In Ushibuka, these HRs were 0.80 (95%CI, 0.24–2.62) and 1.32 (95%CI, 0.42–4.20), respectively.

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