Abstract
The experimental solubility of CBZ (Carbobenzoxy) derivatized amino acids namely N-CBZ valine, N-CBZ proline, N-CBZ aspartic acid in supercritical carbon dioxide were correlated by Soave-Red- lich-Kwong Equation state based on fugacity determination and group contribution method using extrapolated critical parameters and mixing rules and other two different empirical models proposed by Yu (1994) and Gordillo-coworkers (1999). The SRK EOS prediction showed very high deviation of % AARD of 9% - 59%. The Yu model had three derivatized amino acids with average absolute deviation from 2.04, 8.17, 10.96, while the Gordillo model had 0.245, 1.067 and 1.144 for CBZ-valine, CBZ-proline and CBZ-aspartic acid successively. The correlated values had better fit with Gordillo model. The predictive capability and applicability for these amino acid derivatives for both the models demonstrated with correlation coefficient around 0.99 for all the experimental solubility observed.
Highlights
IntroductionGrowing concern on the adverse environmental impact in industrial processing, stringent legislation on the solvent residues in food extracts or products, growing demand by the consumers as well as the processors for safe
Growing concern on the adverse environmental impact in industrial processing, stringent legislation on the solvent residues in food extracts or products, growing demand by the consumers as well as the processors for safeHow to cite this paper: Vedaraman, N., Gadkari, P., Manohar, B., Sandhya, K.V., Brunner, G. and Udaya Sankar, K. (2014) Solubility Modeling of N-CBZ Derivatised Amino Acids in Supercritical Carbon Dioxide
The Psat is very low and it is in the of order 10−12 moles, while solubility is observed of the order 10−5 moles, showing solubility enhancements of the order of 106 to 107 per mole of carbon dioxide is of several thousands
Summary
Growing concern on the adverse environmental impact in industrial processing, stringent legislation on the solvent residues in food extracts or products, growing demand by the consumers as well as the processors for safe. (2014) Solubility Modeling of N-CBZ Derivatised Amino Acids in Supercritical Carbon Dioxide. Some commonly used equation of states that help the modeling of solubility parameter model are Soave-Redlich-Kwong equation of state, Peng-Robinson equation of state, and Lee-Kesler-Plocker equation of state These equations of state are more complicated than empirical or semiempirical model, because it requires more efforts to figure out the unknown constants such as critical temperature, critical pressure, critical volume and acentric factors in the model. The present study is aimed at correlation of the solubility of the N-CBZ amino acids carried out by Vedaraman et al (2004) using 1) Soave Redlich-Kwong equation and empirical models developed by 2) Yu et al (1994) and 3) Gordillo et al (1999)
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