Abstract
Solitary papilloma of the lung is thought to be a rare benign epithelial tumor, and complete surgical resection is currently the standard treatment for this pathology. However, some cases of papilloma have reportedly shown malignant potential. We report two cases of solitary glandular papilloma of the peripheral lung that were treated by thoracoscopic partial resection. The first patient presented with a nodular lesion in the lower lobe of the left lung that was detected on a follow-up chest computed tomography (CT) scan after treatment for laryngeal cancer. Partial lung resection was performed by video-assisted thoracoscopic surgery. In the second patient, a nodular lesion was incidentally identified in the lower lobe of the left lung during a health check-up. Partial lung resection was again performed by video-assisted thoracoscopic surgery. The postoperative course in both cases was uneventful, and no recurrences have been observed as of 44 months and 41 months postoperatively, respectively. To the best of our knowledge, malignant transformation has been reported both with the squamous type and the mixed type of solitary papilloma of the lung. The glandular variant has shown no tendency toward local recurrence after local excision and has no apparent malignant potential. Local excision is thus recommended for solitary glandular papilloma in order to preserve pulmonary function.
Highlights
Solitary pulmonary papilloma is a rare neoplasm that is usually derived from bronchial surface epithelium and forms an endobronchial tumor [1,2,3]
Postoperative histological examination demonstrated that the tumor was comprised of a fibrovascular core and papillomatous fronds lined by pseudostratified columnar epithelium (Figure 1b)
Postoperative histological examination showed the tumor was comprised of a fibrovascular core and papillomatous fronds lined by pseudostratified columnar epithelium (Figure 2b)
Summary
Solitary pulmonary papilloma is a rare neoplasm that is usually derived from bronchial surface epithelium and forms an endobronchial tumor [1,2,3]. Solitary pulmonary papillomas are subclassified into three categories according to histological type: squamous cell papilloma, glandular papilloma, and mixed squamous cell and glandular papilloma (mixed papilloma) [2]. Glandular papilloma of the peripheral lung is uncommon, with only 20 cases reported in the English literature [2,4,5,6,7]. We report two cases of solitary glandular papilloma of the peripheral lung, and discuss the clinical implications of surgery for this
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