Abstract
Benign cephalic histiocytosis (BCH) is a rare type of non-Langerhans histiocytosis with features of many small yellow, yellow-red, or yellow-brown papules located on face, head, neck, and shoulders of infants and young children. There would be no associated symptoms. The histopathological images reveal infiltration of histiocytes in dermis; immunohistochemically, the histiocytes are positive for CD68 stain, but negative for S-100 and CD-1a stain. The BCH would regress spontaneously with time, and thus no treatment is needed. However, in some cases, there would be some pigmentation or atropic scar remained. This is such a rare disease, and thus there is no case of BCH been reported in Taiwan. We recently have a chance to observe an 11-year-old boy with a solitary papule of BCH on his right scalp.
Highlights
Benign cephalic histiocytosis (BCH) is a rare type of nonLangerhans histiocytosis first reported by Gianotti et al [1] in 1971
BCH is a kind of non-Langerhans histiocytosis
There are some reports that BCH may be associated with diabetes mellitus [4] and diabetes insipidus [5], which are worth notice
Summary
Benign cephalic histiocytosis (BCH) is a rare type of nonLangerhans histiocytosis first reported by Gianotti et al [1] in 1971. BCH is a self-limiting disease which may regress spontaneously with only some postinflammatory brown pigments [2] and atropic scars [3] remained. The histopathological pictures of BCH reveal dermal infiltration by histiocyte with positive staining for CD68, but negative for S-100 and CD-1a. It is such a rare disease and there is no case reported in Taiwan before.
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