Abstract
Five complexes were prepared with β-cyclodextrin and the insoluble, non-steroidal, anti-inflammatory drug indomethacin. The complexes were found to contain drug, water and ammonia in several unique combinations. It was theorized the complexes were tri-molecular in nature and their formation was controlled by a hydrophobic/hydrophilic balance created within the β-cyclodextrin ring cavity prior to complex formation. Each complex was characterized by ultraviolet, infrared, nuclear magnetic resonance, powder X-ray diffraction, differential scanning calorimetry, and thermogravimetric techniques. These characterizations revealed distinct differences among the five complexes.
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