Abstract
Molecularly imprinted polymers (MIPs) are synthetic polymers with a predetermined selectivity for a particular analyte or group of structurally related compounds, making them ideal materials for separation processes. Hence, in sample preparation, MIPs are chosen as an excellent material to provide selectivity. Moreover, its use in solid-phase extraction, also referred to as molecular imprinted solid phase extraction (MISPE), is well regarded. In recent years, many papers have been published addressing the utilization of MIPs or MISPE as sorbents in natural product applications, such as synthesis. This review describes the synthesis and characterization of MIPs as a tool in natural product applications.
Highlights
Natural products provide an infinite source for new therapeutic leads, for a treatment of a wide spectrum of disease
The imprinting performance of the templates with three or more functional groups significantly improves with distance between the functional groups
Molecularly imprinted polymers (MIPs) exhibit the inherent qualities of polymers, such as stability, resilience, and ease/low cost of synthesis, when nanoparticles are introduced into their polymeric structure, certain of their characteristics can be increased, and new functions can be produced
Summary
Natural products provide an infinite source for new therapeutic leads, for a treatment of a wide spectrum of disease. Vasapollo et al [11] describes the mechanism in which the template molecule is removed after polymerization, and subsequently, binding sites with similar shape, size, and functionality to the target analyte are generated This results in an imprinted polymer that is stable, robust, and resistant to a wide range of pH, solvents and temperature. The resulting imprints have steric (size and shape) and chemical (spatial arrangement of complementary functionality) memory of the template These imprints enable the polymer to selectively rebind the imprint molecule from a mixture after removing the imprint molecules. In this regard, MIPs with template recognition site of natural products are a useful method for identifying and extracting natural compounds. The influence of these parameters on MIP performance is discussed
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
