Abstract
Tyrosine kinase inhibitors (TKIs) are used as targeted therapy for cancer by inhibiting the signaling pathway and tumor growth. Many TKIs got approved by FDA in recent times for the treatment of cancer by oral route. However, the TKIs have formulation challenges leading to compromised bioavailability which can cause a weak therapeutic response. The cancer nanotherapeutics using nanocarriers based drug delivery has emerged as an advanced tool to provide a solution to formulation challenges and a better cancer therapy by overcoming the limitations in conventional cancer therapy. This review describes the various formulation issues of anticancer drugs with a special reference to TKIs, as well as the capability of solid lipid nanoparticles (SLNs) for an efficient nano targeted cancer drug delivery.
Highlights
36 types of cancers in 185 countries
The lipid-based nanor carriers have drawn attention of researchers to deliver the active agents to the desired target with many advantages over the limitations of other nanocarriers .9 c These solid lipid nanocarriers are capable to address the formulation challenges associated with the Tyrosine kinase inhibitors to improve their bioavailability.[10]
This review summarized the solid lipid nanoparticles (SLN) formulation approach u for delivery of the TKIs with enhanced anticancer potential. n Tyrosine kinase inhibitors
Summary
36 types of cancers in 185 countries. This data is available in Global Cancer Observatory, an online web-based database.[1]. The various targeted therapies use small molecular drugs, monoclonal antibodies and signal transduction inhibitors.[5] The tyrosine kinase inhibitors are nano-materials used to stop cell signaling by inhibiting signal transduction pathway. It has created a new hope in cancer treatment in the current age.[6] the various formulation challenges of TKIs are to be addressed by formulation.
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