Abstract
BackgroundThe biological effects of cigarette smoke are not fully known. To improve our understanding of the action of various chemical agents, we investigated the biodistribution of sodium pertechnetate (Na99mTcO4) in mice exposed to cigarette smoke.MethodsFifteen BALB/c male mice were exposed to the smoke of nine whole commercial cigarettes per day, 3 times/day, for up to 10 days to whole body exposure in a chamber. A control group of 5 BALB/c male mice was sham-smoked. One day later, the exposed and control groups of mice received (7.4 MBq/0.3 ml) of Na99mTcO4 before being killed at 30 min. Bones, brain, heart, intestine, kidney, liver, lungs, muscle, pancreas, spleen, stomach, testis and thyroid were weighed and these organs and blood radioactivity recorded with a gamma counter. The percentage per gram of tissue of injected dose (%ID/g) was determined for each organ.ResultsCigarette smoke significantly decreased (p < 0.05) the %ID/g in red blood cells, bone, kidney, lung, spleen, stomach, testis and thyroid of the exposed mice.ConclusionThe toxic effects of cigarette smoke reduced the Na99mTcO4 biodistribution.
Highlights
The biological effects of cigarette smoke are not fully known
We evaluated the biodistribution as an experimental model to understand the action of various chemical agents [13,14,15,16]
The effects of Cigarette smoking (CS) on the biodistribution of Na99mTcO4 in isolated organs can first be seen in Table 1, which shows that CS decreased the %ID/g in red blood cells, bone, http://www.biomedcentral.com/1471-2385/5/1
Summary
The biological effects of cigarette smoke are not fully known. To improve our understanding of the action of various chemical agents, we investigated the biodistribution of sodium pertechnetate (Na99mTcO4) in mice exposed to cigarette smoke. Tobacco can be smoked in cigarettes, cigars, pipe, water pipes, or chewed. It is as an important cash crop, and has vast economical impact affecting the livelihoods of the farmers growing it, the companies that manufacture it, and the healthcare system that deals with the consequences of using it. Cigarette smoking (CS), the most popular method of smoking tobacco, is one of the most prevalent social habits practiced worldwide today [1]. The World Health Organization estimated that almost 1.1 billion people are smokers. Physicians set norms for morphological or physiological function for each organ by diagnosing a large number of patients. There is diagnostic data for a range of normal (page number not for citation purposes)
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