Abstract
Purpose: Floating drug delivery system reduces the quantity of drug intake and the risk of overloading the organs with excess drug. Methods: In the present study, we prepared the blends of sodium alginate with polyethylene glycol (PEG) and polyethylene oxide (PEO) as a matrix, sodium hydrogen carbonate as a pore forming agent, methyl cellulose as a binder and barium chloride containing 10% acetic acid as a hardening agent. Different ratios of pore forming agent to the polymer blend was used to prepare the floating beads with different porosity and morphology. Ciprofloxacin hydrochloride was used as a model drug for the release kinetics studies. Results: The beads were characterized by optical and FESEM microscopy to study the morphology and pore dimensions. The results obtained shows decrease in beads size with increase in the concentration of the pore forming agent. The swelling properties of the beads were found to be in the range of 80% to 125%. The release kinetics of the ciprofloxacin from the beads was measured by UV-Visible spectroscopy at λmax of 278nm and the results shows for highly porous beads. Conclusion: By varying the amount of alginate and pore forming agent the release kinetics is found to get altered. As a result, ciprofloxacin hydrochloride release is found to be sustained from the blended beads.
Highlights
The primary aim of the controlled drug delivery system is to deliver the drug for longer period of time to achieve better bioavailability
FT-IR spectral analysis Alginate with polyethylene glycol (PEG)/polyethylene oxide (PEO) was chosen as a matrix to carry the drug as it is a biodegradable and biocompatible polymer
The molecular interaction of sodium alginate with PEG/PEO loaded ciprofloxacin beads was studied by using FT-IR spectrophotometer (Figure 1) (JSM-6700 F, JEOL Ltd)
Summary
The primary aim of the controlled drug delivery system is to deliver the drug for longer period of time to achieve better bioavailability. PEG a hydrophilic agent which promotes water uptake into the tablets, so that it undergoes complete gelation within few hours. Oral controlled absorption system enables the sustained release of drug throughout
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