Abstract
To elucidate the possible involvement of oxidant tissue damage and protective effect of skin superoxide dismutase (SOD) activity during contact dermatitis, we investigated SOD activity in the skin of guinea pigs after elicitation of either allergic or primary irritant contact dermatitis. Remarkably decreased skin SOD activity was observed after induction of irritant contact dermatitis but not after elicitation of the allergic type. Although chronic allergic contact dermatitis affects the skin SOD activity, it seems likely that, in an experimental model, the skin SOD activity level is more readily reduced in response to the severe inflammation or tissue injury induced by irritant contact dermatitis than in response to allergic contact dermatitis. The data suggest that if we have the ability to down-regulate the expression of contact dermatitis, it is required, as one of the possibilities, to suppress oxidant tissue damage by manipulating cytoprotection activity against oxidative attacks to the skin.
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