Abstract

上皮细胞-间质细胞转换是控制多细胞生物形态发生的重要过程,与肾脏纤维化、癌症等疾病有关.该现象也发生在眼科的一些难治性病变中,如增生性玻璃体视网膜病变(PVR)、增生性糖尿病视网膜病变(PDR)以及青光眼滤过口纤维化形成等.Snail基因家族是诱导上皮-间质细胞转换的关键转录因子.本文对上皮-间质细胞转换在生理和病理情况下的进展、snail基因家族在上皮-间质细胞转换过程中的作用及其与眼部纤维化疾病的关系作一综述。

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