Abstract

We-propose the use of hyperbolas as covariates in piecewise linear regression splines to fit data exhibiting a multi-phase linear response with smooth transitions between phases. The hyperbolic regression spline model, fitted by non-linear regression, provides an intuitive and easy way to extend to multiple phases the two-phase hyperbolic response model previously proposed by others. The small additional effort required to fit non-linear, as opposed to linear, regression models is particularly worthwhile when investigators are unwilling to assume that the slope of the response changes abruptly at the join points. Furthermore, undue influence on the join point and slope estimates, resulting from points in the transition region, may be avoided by using the hyperbolic regression spline. Two examples illustrate the use of this method.

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