Abstract
Digital microfluidic biochips are gaining increasing attention with promising applications for automating and miniaturizing laboratory procedures in biochemistry. Automated design of digital microfluidic biochips includes two major parts: fluidic-level synthesis and chip-level design. In fluidic-level synthesis, sample/reagent droplets are scheduled along their routing paths for mixing/detection operations. In chip-level design, the underlying electrodes for driving the droplets’ movements are connected to the peripheral control pins. The electrowetting technology is thus enabled by applying different voltages at the peripheral control pins. This chapter describes how a digital microfluidic biochip is designed. Moreover, the automatic control logic is described, where cyberphysical sensors can be integrated for dynamic error recovery in real-life biochemical applications.
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