Abstract
Definitive cytomorphologic diagnosis of small cell carcinoma of the uterine cervix is possible but can be challenging in routine cervicovaginal cancer screening specimens. Several small series of reported cases of cervical small cell carcinoma have shown this uncommon malignancy to represent fewer than 2% of all invasive cervical cancers. This tumor type is associated with poor prognosis and rapid disease progression and can develop to an advanced stage in the interval between screening visits. Only rare case reports of small cell carcinoma arising in gravid cervices are known. In the current case a 29-year-old, gravida 6, para 2, pregnant (10-week gestation) female presented with postcoital bleeding. A definitive diagnosis of small cell carcinoma of the cervix was made possible by liquid based Pap testing with ancillary cell block preparation allowing for immunocytochemical characterization of the lesional cell population.
Highlights
The current World Health Organization (WHO) classification of tumors of the female genital organs describes four uncommon types of primary cervical neuroendocrine neoplasms
Some small series and individual case reports of patients with cervical small cell carcinoma are known in the literature; only very rare reports of this disease being initially diagnosed in gravid cervices are known
We report a case of uterine cervical small cell carcinoma diagnosed in a 29-year-old, pregnant female who presented with postcoital bleeding
Summary
The current World Health Organization (WHO) classification of tumors of the female genital organs describes four uncommon types of primary cervical neuroendocrine neoplasms. These include carcinoid tumor, atypical carcinoid tumor, large cell neuroendocrine carcinoma, and small cell carcinoma [1]. We report a case of uterine cervical small cell carcinoma diagnosed in a 29-year-old, pregnant female who presented with postcoital bleeding. As part of her evaluation, she underwent liquid based Pap testing with the additional step of cell block preparation allowing for immunocytochemical characterization of the lesional cell population and definitive diagnosis
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