Abstract
The calcitonin peptide (Ct) family includes intrinsically disordered peptides which function as hormones (regulating glucose levels in the blood, calcium resorption in the bone, vasodilation and the transmission of pain signals, and triggering migraine attacks). They have highly conserved sequence elements, share key structural features, and bind to similar receptors. Their characterization is extremely challenging due to their low molecular weight and size, the absence of persistent secondary structure, and the high propensity of some Ct sequences to aggregate into pathological amyloid fibers. Using nanosecond laser-pump spectroscopy, in combination with other techniques, allows quantifying structural and dynamical features of these IDPs which are important for their function and pathological aggregation.
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