Abstract
There has been no information about the correlations between body weight distribution and lipoprotein metabolism in terms of high-density lipoproteins-cholesterol (HDL-C) and cholesteryl ester transfer protein (CETP). In this study, we analyzed the quantity and quality of HDL correlations in young women (21.5 ± 1.2-years-old) with a slim (n = 21, 46.2 ± 3.8 kg) or plump (n = 30, 54.6 ± 4.4 kg) body weight. Body weight was inversely correlated with the percentage of HDL-C in total cholesterol (TC). The plump group showed 40% higher body fat (26 ± 3 %) and 86% more visceral fat mass (VFM, 1.3 ± 0.3 kg) than the slim group, which showed 18 ± 2% body fat and 0.7 ± 0.2 kg of VFM. Additionally, the plump group showed 20% higher TC, 58% higher triglyceride (TG), and 12% lower HDL-C levels in serum. The slim group showed 34% higher apoA-I but 15% lower CETP content in serum compared to the plump group. The slim group showed a 13% increase in particle size and 1.9-fold increase in particle number with enhanced cholesterol efflux activity. Although the plump group was within a normal body mass index (BMI) range, its lipid profile and lipoprotein properties were distinctly different from those of the slim group in terms of CETP mass and activity, HDL functionality, and HDL particle size.
Highlights
Maintenance of a slim body shape is greatly desired for health and beauty purposes, especially in young women
Participants were of normal body weight and body mass index (BMI) but were divided into a plump group and slim group
The plump group showed 1.2- and 1.6-fold higher serum total cholesterol (TC) and TG levels, respectively, than the slim group, all TC and TG levels were within their normal ranges (Table 2)
Summary
Maintenance of a slim body shape is greatly desired for health and beauty purposes, especially in young women. There has been no information about the correlations between body weight distribution and lipoprotein metabolism. It is well known that serum high-density lipoprotein-cholesterol (HDL-C) level is inversely correlated with the incidence of coronary artery disease [1]. HDL plays important roles in promoting anti-atherosclerotic, anti-diabetic, and anti-thrombotic activities [2] in serum and interacts with many antioxidant enzymes such as paraoxonase [3, 4]. HDL can be altered under various health conditions [5], such as changed dietary patterns [6], pathogen infection [7], and environmental stress [8]. HDL-C may be a good biomarker for the diagnosis of many diseases and disease progression by
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