Abstract
Sleep issues are common in children with genetic disorders and contribute to their symptom burden. Genetic disorders present unique opportunities for elucidating mechanisms that underlie sleep disturbances. Integration of basic science, translational, and clinical research on genetic disorders facilitates an enhanced understanding of their associated sleep issues and development of targeted treatments. Particular genetic disorders will be discussed including Down syndrome, sickle cell disease, mucopolysaccharidoses, craniofacial syndromes, Wolfram syndrome, Smith-Magenis syndrome, Angelman syndrome, Prader-Willi syndrome, CHARGE syndrome, Williams syndrome, Niemann-Pick disease type C, Rett syndrome, Fragile X syndrome, tuberous sclerosis, and neurofibromatosis type 1.
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