Abstract
Endocrine diseases may result in changes in cutaneous function and morphology, which cause various skin manifestations, including nonspecific or pathognomonic signs. Some of these manifestations are already known dermatologic diseases with only increased frequency in this patient group. As a result the skin may the play role of a screen displaying endocrine disorders, either due to hormone excess or deficiency. Awareness of the skin manifestations may permit prompt and adequate approach to the patients, and therefore facilitate the early diagnosis of the endocrine disease and even be life saving. Some of these manifestations may be recognized clinically, but sometimes they need to be confirmed histopathologically. In this article, many endocrine diseases and their associated skin lesions will be reviewed briefly.
Highlights
Endocrine diseases may result in changes in cutaneous function and morphology, which cause various skin manifestations, including nonspecific or pathognomonic signs
Endocrine diseases may result in skin manifestations, either due to hormone excess or deficiency (Table I)
The microscopic findings of the most frequent skin manifestations will be summarized in this article
Summary
Acanthosis nigrigans may be present in patients with acromegaly, hyperprolactinemia, diabetes mellitus (DM), Cushing’s syndrome, and excessive androgen production. Slight hyperpigmentation of the basal cell layer can be seen, but the dark color of the lesion is due to hyperkeratosis rather than melanin. As a manifestations of Cushing’s syndrome, acne can be seen together with skin thinning, purpura, hirsutism and striae distensea. The acneiform lesions associated with hypercorticism, are commonly seen on the face, neck, and shoulders. A common clinical finding of hyperandrogenemia in women is severe acne vulgaris, accompanying thickened and coarse skin, the enlargement of pores on the face, excessive oiliness. In the microscopic examination of acneiform lesions, the formation of comedone due to dilatation and thinning of the follicular epithelium and a keratotic plug with some sebaceous material are the characteristic findings
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
