Abstract
A technique to determine the size distribution of microbubbles in echo contrast agents is presented. The experimental apparatus consists of three confocally positioned acoustic transducers, two of which serve as transmitters and the other serves as a receiver. One transmitter transmits tone bursts at a fixed frequency higher than the resonance frequencies of the microbubbles, while the other transmitter transmits tone bursts whose center frequencies are swept through the range of resonance frequencies of the microbubbles. Scattered tone bursts are detected by the receiver and recorded by a digital oscilloscope and a computer. A two-dimensional power spectrum is obtained by calculating the spectrum of the received signal as a function of the sweeping frequency. Amplitudes of the second harmonic of the sweeping frequency [D. L. Miller, Ultrasonics 19, 217–224 (1981)] as well as the combination frequencies [V. L. Newhouse and P. Mohana Shankar, J. Acoust. Soc. Am. 75, 1473–1477 (1984)] are used to calculate the size distribution of the microbubbles.
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