Abstract
The site of airway obstruction in asthmatics may be in the central or peripheral airways. Recent studies with air and 80% helium/20% oxygen maximal expiratory flow-volume curves have suggested that this obstruction was predominantly in the central airways unless there were complicating clinical factors such as chronic bronchitis, recurrent respiratory infection or smoking. Others have indicated that peripheral airway obstruction is present in some asymptomatic asthmatics. Using air and 80% helium-20% oxygen maximal expiratory flow-volume curves and measurements of pulmonary mechanics, we studied the site of airway obstruction in asthmatic children without the above clinical factors and found it to be in the central or peripheral airways or both.
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