Abstract
BackgroundOur purpose was to determine if SIRT1 (rs4746720, rs3740051) genotypes have an influence on the development of pituitary adenoma (PA).MethodsThe study group included 142 patients with pituitary adenoma (PA) and the control group consisted of 826 healthy people. The genotyping of SIRT1 (rs4746720, rs3740051) was carried out using the real-time polymerase chain reaction method.ResultsStatistically significant results were obtained in the analysis of SIRT1 rs3740051. Significant differences in genotype (G/G, G/A, A/A) distribution were obtained comparing patients with PA without recurrence and PA with recurrence (0, 17.9, 82.1% vs. 6.7, 6.7, 86.7%, respectively, p = 0.022). Also, statistically significant differences were observed when comparing the genotype (G/G, G/A, A/A) distribution in the non-invasive PA group and the invasive PA group (3.4, 25.9, 70.7% vs. 0, 8.3, 91.7%, respectively, p = 0.003), and allele G was less frequently observed in invasive PA, than in non-invasive PA (4.2% vs. 16.4%, p < 0,001). Further analysis revealed that G/A (OR = 0.261; 95% CI:0.099–0.689; p = 0.007) and each allele A (OR = 0.229; 95% CI:0.091–0.575; p = 0.002) were associated with lower odds of occurring an invasive PA.ConclusionsOur study revealed that SIRT1 rs3740051 is associated with PA recurrence and invasiveness. The haplotype containing alleles C-A in rs12778366-rs3740051 was found to be associated with increased odds of PA development as well.
Highlights
Our purpose was to determine if SIRT1 genotypes have an influence on the development of pituitary adenoma (PA)
The frequency of genotypes and alleles of rs3740051 in patients with PA and control subjects While the SIRT1 rs4746720 polymorphism was not involved in statistical analysis because genotyping results showed only wild type genotype for all study subjects, the genotyping of SIRT1 rs3740051 was performed successfully and the genotype distribution did not deviate from Hardy–Weinberg equilibrium (HWE) (p > 0.05)
We previously found that the carriers of the minor allele C at SIRT1 rs12778366 had an increased risk of PA development [27]
Summary
Our purpose was to determine if SIRT1 (rs4746720, rs3740051) genotypes have an influence on the development of pituitary adenoma (PA). There is no capsule to isolate this soft tumour from microglia and the surrounding structures can be infiltrated by the growing tumour [2]. According to their size PAs can be classified as microadenomas and macroadenomas [2]. A study by Daly et al revealed that the prevalence of PAs is one case in 1064 individuals [7]. Few studies have found age-adjusted incidence rate of PA is 2.7–2.87 cases
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